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Absolute Monocyte Count (Automated)

Complete Blood Count

Absolute monocytesAMCMonocyte absolute count

Review status

Currently under review

Pending specialist review and validation.

What it shows

The Absolute Monocyte Count (Automated) measures the number of monocytes in your blood. Monocytes are a type of white blood cell that help defend against infections, remove damaged cells, and coordinate immune responses.

This value is generated by an automated hematology analyzer as part of a complete blood count with differential. Reporting the absolute count, rather than just a percentage, helps your clinician understand your immune cell levels more precisely and track changes over time.

Why it matters

Your monocyte count can change with infections, inflammation, recovery from illness, and certain blood or bone marrow conditions. Clinicians use this test to help evaluate symptoms such as fever, fatigue, swollen lymph nodes, or unexplained inflammation, and to monitor known conditions or treatments that affect the immune system.

An increased count can be seen in some chronic infections and inflammatory disorders, and in specific blood diseases. A decreased count can occur with some medications, bone marrow suppression, or severe illness. Understanding the pattern alongside other parts of the complete blood count helps guide next steps.

Understanding your results

Results are interpreted in the context of your symptoms, medical history, and other blood counts. A higher result, often called monocytosis, can be associated with chronic infections, inflammatory or autoimmune conditions, recovery after an acute infection, and some hematologic diseases. A lower result, sometimes called monocytopenia, can be related to certain medications, bone marrow suppression, or severe infection.

If your value is outside the expected range, your clinician may repeat the test, review your medications, and assess other components of the complete blood count. In some situations a blood smear review or referral to a specialist is considered. Most single, mild abnormalities are monitored over time to see if they persist or resolve.

Reference ranges

0.10.9 10⁹/L
All sexes
0 days – 2 days
0.11.9 10⁹/L
All sexes
2 days – 8 days
0.11.4 10⁹/L
All sexes
8 days – 1 month
0.10.9 10⁹/L
All sexes
1 month – 2 years
00.8 10⁹/L
All sexes
2 years – 150 years

Reference intervals vary by laboratory, analyzer, methodology, population, and units. The ranges shown here are for education only. Always interpret your results against the reference interval printed on your own lab report.

Factors that could impact Absolute Monocyte Count (Automated)

  • Recent infection or recovery

    Monocytes often rise as you recover from an acute infection or surgery, and may normalize as healing progresses.

  • Medications and therapies

    Corticosteroids, chemotherapy, immunosuppressants, and growth factors can lower or raise monocyte counts.

  • Inflammation and autoimmune disease

    Chronic inflammatory conditions, such as autoimmune disorders, can increase monocyte production and circulation.

  • Sample quality and analyzer flags

    Clotted samples, delays to the lab, or interfering particles can affect automated counts and may prompt a smear review.

  • Age and physiologic variation

    Expected ranges differ across ages. Trends over time are often more informative than a single isolated result.

  • Pregnancy and physiologic stress

    Normal immune shifts in pregnancy and acute stress can modestly affect white blood cell distributions, including monocytes.

2026

References

  1. McGill University Health Centre. (2015, September 14). Abs. Monocyte Automated (Task CD 316968). Laboratory reference ranges.
  2. Tefferi, A., Hanson, C. A., & Inwards, D. J. (2005). How to interpret and pursue an abnormal complete blood cell count. Mayo Clinic Proceedings, 80(7), 923–936.
  3. Briggs, C., Culp, N., Davis, B., d'Onofrio, G., Zini, G., & Machin, S. J. (2014). ICSH guidelines for the standardization of the automated differential leukocyte count. International Journal of Laboratory Hematology, 36(2), 123–132.