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Aspergillus fumigatus IgG

Microbiology & Infection

A. fumigatus IgGAfum IgGAspergillus fumigatus precipitating antibodiesAspergillus IgG

Review status

Currently under review

Pending specialist review and validation.

What it shows

This blood test measures IgG antibodies that your immune system makes against Aspergillus fumigatus, a common mold found in soil, dust, and indoor environments. IgG antibodies reflect past or ongoing exposure and tend to persist, which helps clinicians assess longer-term interactions between you and this mold.

Clinicians use this test alongside your symptoms, chest imaging, and other laboratory studies to evaluate conditions such as chronic lung colonization or infection and certain allergic lung diseases related to Aspergillus. The result on its own does not diagnose or rule out disease, so it is interpreted in context.

Why it matters

Results can support the diagnosis of chronic pulmonary aspergillosis, aspergilloma, or hypersensitivity-related conditions when your clinical picture and imaging fit. Tracking antibody levels over time, ideally using the same method, may help monitor response to treatment and stability of disease.

Your clinician may order this test if you have a long-lasting cough, breathlessness, fatigue, coughing up blood, or lung cavities or nodules on scans, especially if you have underlying lung disease. It is often paired with tests such as Aspergillus IgE, galactomannan, fungal cultures, and high-resolution CT to provide a clearer picture.

Understanding your results

A higher antibody level suggests your immune system has recognized Aspergillus fumigatus and may support a diagnosis when combined with your symptoms, examination, and imaging. Some people with frequent environmental exposure can have detectable antibodies without active illness, so results are weighed against other findings.

If you take medicines that suppress the immune system or have conditions that weaken immunity, you might not produce typical amounts of antibody. In that case, a low result does not fully exclude disease. When results are unexpected, your clinician may repeat the test, use the same laboratory for follow-up, or add other tests and imaging before deciding on next steps.

Reference ranges

039.99 mg/L
All sexes
0 days – 150 years

Reference intervals vary by laboratory, analyzer, methodology, population, and units. The ranges shown here are for education only. Always interpret your results against the reference interval printed on your own lab report.

Factors that could impact Aspergillus fumigatus IgG

  • Recent antifungal therapy

    Treatment with antifungal drugs can reduce fungal burden and may gradually lower antibody levels, so timing relative to therapy can influence results and trends.

  • Immune suppression

    Transplant medicines, chemotherapy, high-dose steroids, and advanced HIV can blunt antibody production, leading to lower-than-expected values even when disease is present.

  • Assay differences and trends

    Different laboratories and methods use different calibrators and cutoffs, so absolute values are not interchangeable. Use the same lab for repeat testing to follow trends reliably.

  • Environmental exposure

    Frequent exposure to mold in work or home environments can stimulate antibodies without active lung disease, which can contribute to a positive result.

  • Underlying lung conditions

    Conditions like prior tuberculosis, COPD, bronchiectasis, or lung cavities increase the risk of chronic Aspergillus disease and can influence how results are interpreted.

  • IVIG or recent transfusion

    Intravenous immunoglobulin and plasma products can passively transfer antibodies, occasionally causing transient false-positive results.

  • Sample quality and timing

    Severely hemolyzed or lipemic samples may affect assay performance. Collecting samples when you are clinically stable helps with comparison over time.

  • Cystic fibrosis and bronchiectasis

    People with these conditions often have recurrent exposure to Aspergillus, so antibodies may be present. Results should be interpreted together with symptoms and imaging.

2026

References

  1. McGill University Health Centre. (2015, October 29). Aspergillus Fumigatus IgG (Task CD 4454104). Laboratory reference ranges.
  2. Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. H., & Bennett, J. E. (2016). Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clinical Infectious Diseases, 63(4), e1–e60. https://doi.org/10.1093/cid/ciw326 External link
  3. Denning, D. W., Cadranel, J., Beigelman-Aubry, C., Ader, F., Chakrabarti, A., Blot, S., Ullmann, A. J., Dimopoulos, G., & Lange, C. (2016). Chronic pulmonary aspergillosis: Rationale and clinical guidelines. European Respiratory Journal, 47(1), 45–68. https://doi.org/10.1183/13993003.00583-2015 External link
  4. Mayo Clinic Laboratories. (2023). Aspergillus fumigatus, IgG antibodies, serum (Test ID: ASPGG). External link