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BG Anion Gap Mixed

Immunology & Autoimmune

AGAnion gap (blood gas, mixed venous)

Review status

Currently under review

Pending specialist review and validation.

What it shows

BG Anion Gap Mixed is a calculated value reported from a blood gas test on mixed venous blood. It compares the major measured electrolytes to estimate the balance between positively and negatively charged particles in your blood.

Because it is derived from measurements on the blood gas analyzer, it reflects your acid base status at the time of sampling and can change quickly with treatment or illness. It is often ordered with pH, bicarbonate, oxygen, and carbon dioxide as part of an evaluation of breathing and metabolism.

Why it matters

Clinicians use the anion gap to help identify causes of metabolic acidosis and other acid base disorders. An increased gap can point toward the presence of unmeasured acids, which may occur with kidney problems, diabetic ketoacidosis, lactic acidosis, or certain poisonings. A decreased gap is less common and may be related to low albumin or specific proteins in the blood.

This test is often ordered in emergency and critical care settings, during evaluation of shortness of breath or confusion, before or after major surgery, or when monitoring kidney disease or severe infections. It can guide decisions about further testing and treatment, including fluids, insulin, or antidotes when appropriate.

Understanding your results

Your result is interpreted together with your symptoms and other tests such as pH, bicarbonate, electrolytes, lactate, ketones, kidney and liver function, and a review of medications and exposures. A higher value suggests extra acids in the blood; a lower value may reflect laboratory or physiological factors.

If your value is outside the expected range, your clinician may repeat the test, confirm serum electrolytes, and consider adjustments for albumin level. Depending on the situation, follow up tests can include lactate, ketones, urinalysis, toxicology screens, or imaging. Most causes are treatable once identified, and trends over time are usually more informative than a single value.

Reference ranges

515 mmol/L
All sexes
0 days – 150 years

Reference intervals vary by laboratory, analyzer, methodology, population, and units. The ranges shown here are for education only. Always interpret your results against the reference interval printed on your own lab report.

Factors that could impact BG Anion Gap Mixed

  • Sample handling and timing

    Exposure of the sample to air, delayed analysis, or vigorous mixing can change bicarbonate and carbon dioxide, which alters the calculated gap.

  • Intravenous fluids and nutrition

    Recent infusions of saline, bicarbonate, or lactate containing solutions, and total parenteral nutrition, can shift electrolytes and affect the result.

  • Albumin and proteins

    Low albumin reduces the gap and may mask acid accumulation; certain abnormal proteins can lower it as well.

  • Medications and toxins

    Diuretics, lithium, salicylates, metformin, antiretrovirals, methanol, ethylene glycol, and propylene glycol can change acid production or electrolytes.

  • Renal, hepatic, and circulatory function

    Kidney failure, advanced liver disease, heart failure, or shock can raise organic acids or impair their clearance, influencing the gap.

  • Special populations

    Pregnancy, extreme ages, and critical illness can modify acid base balance; results should be interpreted in that context.

2026

References

  1. McGill University Health Centre. (2020, March 18). BG Anion Gap Mixed (Task CD 1092139). Laboratory reference ranges.
  2. American Diabetes Association. (2024). 16. Diabetes care in the hospital and hyperglycemic crises: Standards of care in diabetes. Diabetes Care, 47(Suppl. 1), S1–Sxxx.
  3. Kraut, J. A., & Madias, N. E. (2007). Serum anion gap: Its uses and limitations in clinical medicine. Clinical Journal of the American Society of Nephrology, 2(1), 162–174.
  4. American College of Medical Toxicology & American Academy of Clinical Toxicology. (2020). Guidance for the management of ethylene glycol and methanol poisoning.