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Bicarbonate Level

Electrolytes

CO2HCO3-Serum bicarbonateTotal CO2

Review status

Currently under review

Pending specialist review and validation.

What it shows

A bicarbonate test measures the amount of bicarbonate in your blood. Bicarbonate is a base that helps keep your body’s acid-base balance steady. It is the main form in which carbon dioxide travels in the bloodstream, working closely with your lungs and kidneys to keep your blood pH within a healthy range.

This test is commonly included in a basic or comprehensive metabolic panel. It provides a snapshot of how your body is handling acids and bases at the time of the blood draw.

Why it matters

Bicarbonate helps clinicians assess acid-base status, which can be disrupted by conditions affecting breathing, kidney function, or fluid balance. It is often checked when you have symptoms such as shortness of breath, confusion, nausea, or when you are being evaluated for illnesses like kidney disease, diabetes complications, or lung disorders.

Results can guide treatment decisions in clinics, emergency departments, and hospitals. Tracking bicarbonate over time can show whether therapies, such as diuretics or treatments for infections or kidney problems, are helping restore a healthy acid-base balance.

Understanding your results

A lower bicarbonate result generally suggests that your blood is more acid than it should be, which can occur with kidney problems, severe infections, certain poisonings, or diarrhea. A higher result can occur when you lose acid or gain base, such as with vomiting, some water pills, or the body’s response to long-standing lung disease.

Your care team will interpret your result together with your symptoms, other electrolytes, kidney tests, and sometimes a blood gas measurement. If a result is unexpected, they may repeat the test, review your medicines and supplements, and order additional studies to identify the cause and choose the best next steps.

Reference ranges

2329 mmol/L
All sexes
0 days – 150 years

Reference intervals vary by laboratory, analyzer, methodology, population, and units. The ranges shown here are for education only. Always interpret your results against the reference interval printed on your own lab report.

Factors that could impact Bicarbonate Level

  • Sample handling and air exposure

    If the blood tube is not filled and sealed properly, carbon dioxide can escape, falsely lowering the measured bicarbonate. Prompt processing and minimal air contact reduce this error risk.

  • Recent breathing changes

    Rapid breathing or breath-holding can shift acid-base balance within minutes and temporarily affect bicarbonate. Resting quietly before the draw improves consistency.

  • Medications and supplements

    Diuretics, bicarbonate-containing antacids, acetazolamide, steroids, and some antibiotics can raise or lower bicarbonate. Share a complete list of medicines and over-the-counter products.

  • Fluid losses and diet

    Vomiting, diarrhea, or aggressive laxative use can alter acid or base levels. Very low carbohydrate or high-protein diets may also influence acid production.

  • Chronic health conditions

    Kidney disease, adrenal disorders, diabetes complications, and chronic lung disease affect how your body handles acids and bases. These conditions guide how results are interpreted.

  • Pregnancy and age

    Normal physiologic changes in pregnancy and aging can slightly shift acid-base balance. Your clinician accounts for these factors when reviewing your result.

2026

References

  1. McGill University Health Centre. (2015, July 09). Bicarbonate Level (Task CD 316582). Laboratory reference ranges.
  2. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. (2024). KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International Supplements.
  3. McPherson, R. A., & Pincus, M. R. (Eds.). (2023). Henry’s Clinical Diagnosis and Management by Laboratory Methods (24th ed.). Elsevier.