Platform
Company
Endocrine & Reproductive
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Currently under review
Pending specialist review and validation.
Prolactin is a hormone made by the pituitary gland that supports milk production, reproductive function, and sexual health. This test measures the amount of prolactin circulating in your blood at baseline, either as a single check or as the starting sample in a dynamic pituitary study.
Your blood is drawn from a vein. Some laboratories prefer a calm, morning collection because stress, recent exercise, or nipple stimulation can temporarily raise prolactin levels. The measurement helps your clinician understand how your pituitary and related systems are functioning.
Clinicians order prolactin testing for symptoms such as unexpected breast milk discharge, irregular or absent periods, infertility, low libido, or erectile dysfunction. It is also used when headaches or vision changes raise concern for a pituitary problem, and to monitor known prolactin producing tumors or the effects of treatment.
Results can help distinguish medication effects, thyroid disease, pregnancy, and kidney or liver conditions from pituitary causes. Tracking results over time guides decisions about medication that lowers prolactin, the need for imaging, and other care plans tailored to your situation.
A higher than expected result is common and may reflect stress during the blood draw, certain medications, or physiologic states like pregnancy and breastfeeding. If your level is elevated, your clinician may repeat the test under calmer conditions, review your medications, and check thyroid function. Sometimes a specialized check for macroprolactin is done, since this form can raise results without causing symptoms.
A low result is less common and usually has limited clinical impact, but in the right context it can point to pituitary or hypothalamic issues. If results remain abnormal without a clear explanation, your clinician may order additional tests or imaging of the pituitary and discuss the next steps with you.
Reference intervals vary by laboratory, analyzer, methodology, population, and units. The ranges shown here are for education only. Always interpret your results against the reference interval printed on your own lab report.
Prolactin follows a daily rhythm and rises with stress. A quiet, morning blood draw after resting can reduce temporary elevations and give a more stable baseline result.
Breast or chest stimulation and sexual activity can transiently increase prolactin. Avoid these activities for several hours before your test when possible.
Antipsychotics, antidepressants, antiemetics like metoclopramide, some blood pressure medicines, and high estrogen exposure can increase prolactin. Bring an updated medication list to your appointment.
Untreated hypothyroidism can elevate prolactin. Your clinician may pair prolactin with thyroid testing to identify this reversible cause.
Physiologic states such as pregnancy and lactation naturally raise prolactin. Your clinician interprets results in the context of these conditions.
Reduced clearance in kidney or liver disease can increase prolactin. Interpreting results may require reviewing kidney and liver function tests.
Some people have macroprolactin, a larger form that can elevate results without symptoms. High biotin intake and certain antibodies can also interfere with some assays.
Anxiety, prolonged tourniquet time, or vigorous exercise just before the draw may raise prolactin. Try to rest quietly before sampling.
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