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Sodium

Electrolytes

Na+Serum sodium

Review status

Currently under review

Pending specialist review and validation.

What it shows

The sodium test measures the concentration of sodium in your blood. Sodium is a key electrolyte that helps regulate fluid balance, blood pressure, and how nerves and muscles function.

This test uses a blood sample taken from a vein and is commonly performed with other electrolytes and kidney function tests. Together, these results help your care team understand your overall fluid and electrolyte status.

Why it matters

Keeping sodium in a healthy range is essential for normal brain, nerve, and muscle activity. Levels can shift with dehydration, excess water intake, kidney or heart problems, liver disease, and hormone disorders that affect water and salt balance. Gastrointestinal losses such as vomiting or diarrhea can also affect sodium.

Clinicians order this test to evaluate symptoms like fatigue, confusion, headache, muscle cramps, or seizures, to monitor people receiving diuretics or intravenous fluids, and to guide hospital care. Knowing whether sodium is low or high helps tailor treatment, which may include adjusting fluids, reviewing medications, and treating any underlying condition.

Understanding your results

Your provider will interpret your sodium result in the context of your age, symptoms, medications, and other labs. Small deviations may not need urgent action, while larger or rapid changes can be more serious and require closer monitoring.

If your result is outside the expected range, follow‑up may include repeating the test, measuring related values such as potassium, chloride, osmolality, glucose, and kidney function, and reviewing your fluid intake and losses. Treatment focuses on the cause and is adjusted carefully to avoid changing sodium too quickly.

Reference ranges

131143 mmol/L
All sexes
0 days – 1 month
133143 mmol/L
All sexes
1 month – 150 years

Reference intervals vary by laboratory, analyzer, methodology, population, and units. The ranges shown here are for education only. Always interpret your results against the reference interval printed on your own lab report.

Factors that could impact Sodium

  • Hydration and fluid balance

    Dehydration can raise measured sodium, while excessive water intake or hypotonic fluids can lower it. Recent vomiting, diarrhea, or heavy sweating also shifts sodium.

  • Medications

    Diuretics, antidepressants such as SSRIs, carbamazepine or oxcarbazepine, desmopressin, NSAIDs, and some blood pressure medicines can lower sodium. Corticosteroids or mineralocorticoids can raise it.

  • IV fluids and sample collection

    Drawing blood from or near an IV line that was flushed with saline can falsely raise sodium. Large volumes of hypotonic or hypertonic IV fluids can meaningfully alter results.

  • Kidney and endocrine conditions

    Chronic kidney disease, heart failure, cirrhosis, hypothyroidism, adrenal insufficiency, and inappropriate antidiuretic hormone secretion can all disturb sodium balance.

  • Metabolic and lab method effects

    Marked hyperglycemia can lower measured sodium due to water shifts. Severe hyperlipidemia or very high protein levels may cause spurious low values with some analytical methods.

  • Age and pregnancy

    Newborns have different expected sodium ranges than older children and adults. During pregnancy, normal physiology can slightly lower serum sodium due to plasma volume expansion.

2026

References

  1. McGill University Health Centre. (2015, April 30). Sodium 0m (Task CD 1021415). Laboratory reference ranges.
  2. Spasovski, G., Vanholder, R., Allolio, B., Annane, D., Ball, S., Bichet, D., Decaux, G., Fenske, W., Hoorn, E. J., Ichai, C., Joannidis, M., Soupart, A., Zietse, R., Haller, M., van der Veer, S., Van Biesen, W., & Nagler, E. V. (2014). Clinical practice guideline on diagnosis and treatment of hyponatraemia. European Journal of Endocrinology, 170(3), G1–G47.
  3. Verbalis, J. G., Goldsmith, S. R., Greenberg, A., Korzelius, C., Schrier, R. W., Sterns, R. H., & Thompson, C. J. (2013). Diagnosis, evaluation, and treatment of hyponatremia: Expert panel recommendations. The American Journal of Medicine, 126(10 Suppl 1), S1–S42.